Molecular Mechanisms of Drug Resistance in Bacteria
David Smith
•Harvard Medical SchoolElena Rodriguez
•Pasteur Institute Published: 2025-11-28 DOI: 10.1038/s41586-025-0125
Abstract
Antibiotic resistance poses a severe threat to global health. This paper investigates the molecular mechanisms underlying multidrug resistance in Staphylococcus aureus. Using CRISPR-Cas9 gene editing, we identified three novel gene clusters responsible for efflux pump overexpression. Our findings suggest that targeting these regulatory pathways could restore susceptibility to conventional antibiotics.
Keywords
MicrobiologyDrug ResistanceBacteriaCRISPRGenetics
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